Author

Aubrey Y. Liew

Mayo Clinic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:mechanistic / dynamical model· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Haidong DongiD· 3 shared Ying Li· 3 shared Aaron Scott MansfieldiD· 1 shared Emilia Rae DellaceccaiD· 1 shared Jacob B. HirdleriD· 1 shared Joanina K. GicobiiD· 1 shared Mojun ZhuiD· 1 shared Roxana Stefania DroncaiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

Haidong DongORCID

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3 papers

Recent·Most cited

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8 T Cells Undetectable by Conventional Analyses

Ying Li, Mojun Zhu, Roxana Stefania Dronca, Yiyi Yan, Wenjing Zhang, Yi Lin, Aaron Scott Mansfield, Svetomir N. Markovic, Sean S. Park, Aubrey Y. Liew, Haidong Dong

The paper uses AI to model CD8 T-cell responses during ICI therapy, identifying a latent effector state that conventional methods miss.

bioRxiv · Jul 25, 2026 · PreprintImmunology

ME1 Programs Latent Effector Capacity and Grounds a Mathematical Model of Reversible T Cell Exhaustion

Aubrey Y. Liew, Ying Li, Joanina K. Gicobi, Jacob B. Hirdler, Emilia Rae Dellacecca, Haidong Dong

This paper identifies ME1 as a key regulator of reversible T cell exhaustion and develops a mathematical model to predict ICI responsiveness based on latent effector capacity.

bioRxiv · May 10, 2026 · PreprintImmunology

Latent Effector Capacity Governs Reversible T Cell Exhaustion: A Mathematical Model for Mechanistically Predictive AI in PD-1 Blockade

Aubrey Y. Liew, Ying Li, Haidong Dong

This paper develops a mathematical model to explain reversible T cell exhaustion and its response to PD-1 blockade, identifying latent epigenetic states that govern therapeutic outcomes.

bioRxiv · Apr 17, 2026 · PreprintImmunology