Author

Aaron Scott Mansfield

Mayo ClinicORCID 0000-0002-9483-6903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Farhad KosariiD· 2 shared Janet L. Schaefer-Klein· 2 shared Lin YangiD· 2 shared Mitesh J. BoradiD· 2 shared Panos Z. AnastasiadisiD· 2 shared Alexa McCune· 1 shared Alfredo Quiñones‐HinojosaiD· 1 shared Alyx B. PorteriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Farhad KosariORCID

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Author profile →

4 papers

Recent·Most cited

Functional genomics identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomas

Wan-Hsin Lin, Farhad Kosari, James B. Smadbeck, Michael T. Barrett, Ryan Feathers, Jamie Hall, Dorsay Sadeghian, Sotiris Sotiriou, Sarah H. Johnson, Faye R. Harris, Taylor Berry, Alexa McCune, Stephen James Murphy, Lindsey Kinsella, Lauren Elaine Haydu, , Panos Z. Anastasiadis

This study identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomas using genomic, transcriptomic profiling, and drug testing in patient-derived models.

npj Precision Oncology · Oct 27, 2026Peer-reviewedCancer Biology

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8 T Cells Undetectable by Conventional Analyses

Ying Li, Mojun Zhu, Roxana Stefania Dronca, Yiyi Yan, Wenjing Zhang, Yi Lin, Aaron Scott Mansfield, Svetomir N. Markovic, Sean S. Park, Aubrey Y. Liew, Haidong Dong

The paper uses AI to model CD8 T-cell responses during ICI therapy, identifying a latent effector state that conventional methods miss.

bioRxiv · Jul 25, 2026 · PreprintImmunology

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

Jin Young Lee, Nabora S. Reyes, Sang‐Ho Woo, Nancy C. Allen, Tsukasa Kadota, Andrew J. Lechner, Ritusree Biswas, Sakshi Goel, Fia Stratton, Chaoyuan Kuang, Tatsuya Tsukui, Vincent C. Auyeung, Aaron Scott Mansfield, Lindsay M. LaFave, Tien Peng

This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.

Cell stem cell · Nov 3, 2025Peer-reviewedCancer Biology

Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders

Jayapal Reddy Mallareddy, Lin Yang, Wan‐Hsin Lin, Ryan W. Feathers, Jennifer R. Ayers-Ringler, Ezequiel J. Tolosa, Amritha G. Kizhake, Smitha Kizhake, Sydney P. Kubica, Lidia Boghean, Sophie Alvarez, Michael J. Naldrett, Sarbjit Singh, Sandeep Rana, Muhammad Zahid, , Aaron Scott Mansfield

The paper identifies a potent MET degrader using live cell imaging, showing it is more effective than existing PROTACs.

RSC Advances · Jan 1, 2025Peer-reviewedCancer Biology