Author

Joanina K. Gicobi

Mayo ClinicORCID 0000-0002-2741-0363Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Emilia Rae DellaceccaiD· 2 shared Haidong DongiD· 2 shared Jacob B. HirdleriD· 2 shared Aubrey Y. Liew· 1 shared Daniel D. BilladeauiD· 1 shared Fabrice LucieniD· 1 shared Geoffrey Zhao· 1 shared Henrique Borges da SilvaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Emilia Rae DellaceccaORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 10, 2026

ME1 Programs Latent Effector Capacity and Grounds a Mathematical Model of Reversible T Cell Exhaustion

Aubrey Y. Liew, Ying Li, Joanina K. Gicobi…·Haidong Dong

This paper identifies ME1 as a key regulator of reversible T cell exhaustion and develops a mathematical model to predict ICI responsiveness based on latent effector capacity.

DOI 10.64898/2026.05.05.722814

humanscRNA-seq

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ImmunologybioRxivPreprintJan 18, 2025

PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity

Zhiming Mao, Jacob B. Hirdler, Joanina K. Gicobi…·Haidong Dong

This study identifies PD-1's role in regulating effector potential and exhaustion in thymic CD8+ T cells, showing that PD-1 inhibition enhances expansion but leads to exhaustion in tumor tissues.

1 citation

mousebulk RNA-seq

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