ME1 Programs Latent Effector Capacity and Grounds a Mathematical Model of Reversible T Cell Exhaustion
Aubrey Y. Liew, Ying Li, Joanina K. Gicobi, Jacob B. Hirdler, Emilia Rae Dellacecca, Haidong Dong
This paper identifies ME1 as a key regulator of reversible T cell exhaustion and develops a mathematical model to predict ICI responsiveness based on latent effector capacity.
bioRxiv · May 10, 2026 · PreprintImmunology