Age-related remodeling of the glycocalyx drives T cell exhaustion
Hanlin Zhang, C. Kimberly Tsui, Jesse Garcia Castillo, Esther Jeong Yoon Kim, Audrey Evangelista, Hengchen Liu, Larry K. Joe, Nicholas M. Twells, Ellen A. Robey, Lara K. Mahal, Michel J.P. DuPage, Andrew G. Dillin
This study shows that aging reduces 2,6-linked sialic acids on T cells, leading to exhaustion and impaired immune function.
Science Advances · Sep 26, 2025Peer-reviewedImmunology