Author

Nicholas M. Twells

University of Alberta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Lara K. MahaliD· 4 shared Chuanhao PengiD· 2 shared Eric J CarpenteriD· 2 shared Ratmir DerdaiD· 2 shared Sheng‐Kai WangiD· 2 shared Simatsidk HareguiD· 2 shared Alexxandra Sosa-GuiriD· 1 shared Amika SoodiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiochemistry

Lara K. MahalORCID

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Author profile →

4 papers

Recent·Most cited

Biological recognition of mirror-image glycans

Chuanhao Peng, Simatsidk Haregu, Claire Yi-Ling Yang, Shreyas Gupta, Michael Evjen, Hani Choksi, Vanessa Affe, Eric J Carpenter, Nicholas M. Twells, Mei-Ting Lin, Ayodeji Kulepa, Carolina Ortiz‐Cordero, Alexxandra Sosa-Guir, Jonathan Lefèbre, Szu Yun Wang, , Ratmir Derda

The paper evaluates how glycan-binding proteins and immune cells recognize mirror-image glycans, finding widespread binding and donor-specific recognition of L-glycans.

bioRxiv · Jul 20, 2026 · PreprintBiochemistry

Atom-level Machine Learning of Protein-glycan Interactions and Cross-chiral Recognition in Glycobiology

Eric J Carpenter, Chuanhao Peng, Simatsidk Haregu, Nicholas M. Twells, Logan Woudstra, Amika Sood, Jonathan Cartmell, Robert J. Woods, Lara K. Mahal, Sheng‐Kai Wang, Russell Greiner, Ratmir Derda

This paper develops MCNet, a machine learning model that predicts protein-glycan binding strength using atom-level representations, enabling cross-chiral recognition and unifying diverse glycobiology datasets.

Science Advances · Dec 5, 2025Peer-reviewedBiochemistry

Age-related remodeling of the glycocalyx drives T cell exhaustion

Hanlin Zhang, C. Kimberly Tsui, Jesse Garcia Castillo, Esther Jeong Yoon Kim, Audrey Evangelista, Hengchen Liu, Larry K. Joe, Nicholas M. Twells, Ellen A. Robey, Lara K. Mahal, Michel J.P. DuPage, Andrew G. Dillin

This study shows that aging reduces 2,6-linked sialic acids on T cells, leading to exhaustion and impaired immune function.

Science Advances · Sep 26, 2025Peer-reviewedImmunology

Screening the human miRNA interactome reveals coordinated upregulation in melanoma, adding bidirectional regulation to miRNA networks.

Faezeh Jame-Chenarboo, Joseph N. Reyes, Nicholas M. Twells, Hoi Hei Ng, Dawn Macdonald, Eva Hernando, Lara K. Mahal

The paper identifies miRNAs that upregulate CD98hc and ST3GAL1/ST3GAL2 in melanoma, revealing a bidirectional regulatory mechanism in miRNA networks.

Science Advances · Jan 10, 2025Peer-reviewedCell Biology