Cisplatin-Induced Plasticity Drives Cross-Resistance to CDK4/6 Inhibitors and Reveals Targetable Vulnerabilities Through HDAC Inhibition in Esophageal Squamous Cell Carcinoma.
Marta Ávalos-Moreno, Aurora Vigato, Fabiana Moresi, Diego Japon-Ruiz, Benjamin Beck, Xavier Bisteau
This study shows cisplatin resistance in ESCC leads to an immune-evasive, drug-tolerant state that confers cross-resistance to CDK4/6 inhibitors, which can be reversed by HDAC inhibitors.
bioRxiv · Jul 17, 2026 · PreprintCancer Biology