Xavier Bisteau

This study shows TRMT10A deficiency causes β-cell dysfunction by promoting tRNA fragmentation and disrupting PCSK1 expression, leading to impaired insulin maturation and glucose-stimulated insulin secretion.

This study shows cisplatin resistance in ESCC leads to an immune-evasive, drug-tolerant state that confers cross-resistance to CDK4/6 inhibitors, which can be reversed by HDAC inhibitors.

This study evaluates palbociclib as a first-line therapy in eSCC, identifying response subtypes and showing immune activation through replication stress and DNA damage.