Cancer BiologybioRxivPreprint
Cisplatin-Induced Plasticity Drives Cross-Resistance to CDK4/6 Inhibitors and Reveals Targetable Vulnerabilities Through HDAC Inhibition in Esophageal Squamous Cell Carcinoma.
Marta Ávalos-Moreno, Aurora Vigato, Fabiana Moresi…·Xavier Bisteau
This study shows cisplatin resistance in ESCC leads to an immune-evasive, drug-tolerant state that confers cross-resistance to CDK4/6 inhibitors, which can be reversed by HDAC inhibitors.
DOI 10.64898/2026.07.17.738886