Benjamin Beck

This study shows cisplatin resistance in ESCC leads to an immune-evasive, drug-tolerant state that confers cross-resistance to CDK4/6 inhibitors, which can be reversed by HDAC inhibitors.

The paper shows that GATA4 drives metaplasia and tumorigenesis in esophageal squamous progenitors, but not keratinocytes, and that Hedgehog signaling expansion enhances this process.

This study evaluates palbociclib as a first-line therapy in eSCC, identifying response subtypes and showing immune activation through replication stress and DNA damage.

The paper shows that Sox9-dependent plasticity in esophageal progenitors is regulated by Hedgehog-induced TGF-β and BMP pathways, and can be modulated by Ibuprofen in vivo.