Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice
Kassidy E Grover, Zoe Cappel, Avery M. Volz, Evelin M. Cotella, Kelly Smallwood, Christine A. Berryhill, Kimaya R Raje, Austen A Fisher, Mary Claire T Casper, Diana Nardini, Tilat A. Rizvi, Rosa M. Salazar, Ashley Wooten, Michael T. Williams, Charles V. Vorhees, , J. Elliott Robinson
This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.
Human Genetics and Genomics Advances · May 1, 2026Peer-reviewedGenetics