Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin
Stephanie L. Baringer, Avraham S. Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S. Lippmann, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.
Journal of Neurochemistry · Sep 4, 2023Peer-reviewedNeuroscience