Hyosung Kim

Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

This study shows that intermediate substrate stiffness promotes inflammation in human brain microvascular endothelial cells, which is reduced by fluid shear stress.

IQGAP2 regulates blood-brain barrier immune dynamics

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.

Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

Generalized strategy for engineering mammalian cell-compatible RNA-based biosensors from random sequence libraries

The paper describes a method to engineer RNA-based biosensors for mammalian cells using random sequence libraries, demonstrating a biosensor for L-dopa detection.

Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport

The paper identifies 17β-estradiol and CAT-1 as regulators of leptin transport across an iPSC-derived blood-brain barrier model.

Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

This study shows that OLIG2 overexpression in Down syndrome patient-derived iPSCs leads to abnormal neurodevelopmental phenotypes, including impaired recognition memory in chimeric mice.

Pluripotent Stem Cell-derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

This study uses human pluripotent stem cell-derived cerebral organoids to show that oligodendrogenesis in the human brain has both ventral and dorsal origins, with dorsal cells dominating in fused organoids.