Modeling interregional propagation of α-synuclein in human striatal-midbrain assembloids
Kaneyasu Nishimura, Naoya Amimoto, Yuya Sato, Mieko Morishima, Mamoru Sakaibara, Ayana Haratake, Mai Nakano, Naoko Kaneko, Hideaki Yamamoto, Ayumi Hirano‐Iwata, Takashi Tanii, Jun Takahashi, Kazuyuki Takata, Yoshito Masamizu
This study uses human striatal-midbrain assembloids to show that α-synuclein pathology spreads from the striatum to midbrain dopaminergic neurons, causing functional impairment.
bioRxiv · May 11, 2026 · PreprintNeuroscience