Kaneyasu Nishimura

Disruption of Histone H4C genes impairs skeletal development and cortical neurogenesis, modeling rare neurodevelopmental syndromes

This study shows that mutations in H4C genes disrupt skeletal development and cortical neurogenesis in mice, explaining developmental abnormalities in patients.

Modeling interregional propagation of α-synuclein in human striatal-midbrain assembloids

This study uses human striatal-midbrain assembloids to show that α-synuclein pathology spreads from the striatum to midbrain dopaminergic neurons, causing functional impairment.

Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation.

This study improves human embryonic stem cell differentiation into midbrain dopaminergic neurons using specific factors and reveals developmental dynamics and high-quality cell types through single-cell RNA-sequencing.