Platform of single-molecule enzyme activity-based liquid biopsy for detection of pancreatic adenocarcinoma at early stages
Shingo X. Sakamoto, Hideto Hiraide, Tadahaya Mizuno, Mayano Minoda, N Nagano, Misa Suzuki, Nozomi Iwakura, Ayumu Kashiro, Satoshi Nara, Chigusa Morizane, Susumu Hijioka, Kazufumi Honda, Yu Kagami, Rikiya Watanabe, Yasuteru Urano, Toru Komatsu
This paper introduces a liquid biopsy platform that detects early-stage pancreatic adenocarcinoma by analyzing single-molecule protease/peptidase activity in blood samples.
bioRxiv · Aug 7, 2025 · PreprintBiochemistry