Author

Ayushi Saini

Indian Institute of Technology Kharagpur

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Amit Kumar DasiD· 1 shared Ching‐Seng AngiD· 1 shared Elizabeth HindeiD· 1 shared Isabelle RouilleriD· 1 shared Joydeep BaraliD· 1 shared Kalyan ShobhanaiD· 1 shared Paul J. McMillaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Amit Kumar DasORCID

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1 paper

Recent·Most cited

Bringing the Ends together: Cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis

Joydeep Baral, Ching‐Seng Ang, Paul J. McMillan, Kalyan Shobhana, Ayushi Saini, Elizabeth Hinde, Amit Kumar Das, Isabelle Rouiller

This study presents cryo-EM structures of mycobacterial Ku (mKu) in complex with DNA, revealing its role in NHEJ synapsis and identifying key residues for DNA binding and synaptic assembly.

Nucleic Acids Research · Nov 30, 2025Peer-reviewedBiochemistry