Elizabeth Hinde

Single-molecule bouncing at a liquid interface governs presynaptic enrichment

The paper shows that single-molecule bouncing at a presynaptic interface enables protein enrichment without slowing diffusion.

Osmotic Coupling of Mechanics and Epigenetics Regulates Chromatin Phase Organization

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

SMCHD1's DNA binding activity enables its stable retention on chromatin

This study shows that SMCHD1's weak DNA binding is essential for its chromatin retention and function, revealing how DNA binding affects its localization and gene repression.

Cell cycle dependent regulation of mRNA export in response to replication stress

The paper identifies WEE1, CDK1, and PLK1 as regulators of mRNA export during DNA replication stress, showing their role in preventing R-loop associated mRNA from being exported to the cytoplasm.

Unlocking subcellular imaging of a cnidarian photosymbiont Breviolum minutum , through expansion microscopy

This paper develops an expansion microscopy workflow to visualize subcellular features of Breviolum minutum, a cnidarian photosymbiont, overcoming challenges posed by autofluorescence and small size.

Bringing the Ends together: Cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis

This study presents cryo-EM structures of mycobacterial Ku (mKu) in complex with DNA, revealing its role in NHEJ synapsis and identifying key residues for DNA binding and synaptic assembly.

MORC2 phosphorylation fine tunes its DNA compaction activity

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation

This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.

Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.

PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation.

This study identifies PAK6 as a positive regulator of neuronal autophagy through TFEB nuclear translocation, with implications for neurodegenerative disease treatment.