Paul J. McMillan

This study defines the spatial architecture of human subgingival biofilms using fluorescence in situ hybridization and microscopy, revealing structured microbial consortia associated with periodontitis.

This study shows that Cas13 forms phase-separated RNA condensates to enhance target RNA accessibility and cleavage efficiency in both bacterial and mammalian cells.

This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.

This study presents cryo-EM structures of mycobacterial Ku (mKu) in complex with DNA, revealing its role in NHEJ synapsis and identifying key residues for DNA binding and synaptic assembly.