A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasites
D. W. Cobb, H. M. Kudyba, A. Villegas, M. R. Hoopmann, R. Baptista, B. Bruton, M. Krakowiak, R. L. Moritz, V. Muralidharan
This study identifies a druggable oxidative folding pathway in the ER of P. falciparum, showing that PfPDI8 is essential and sensitive to small molecule inhibition.
bioRxiv · May 13, 2020Microbiology