D. W. Cobb

Rapid, time-resolved proximity labeling by SBP1 identifies a porin domain protein at the malaria parasite periphery

This study uses SBP1TbID to identify proteins involved in exporting membrane proteins from the malaria parasite periphery.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasites

This study identifies a druggable oxidative folding pathway in the ER of P. falciparum, showing that PfPDI8 is essential and sensitive to small molecule inhibition.

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites.

This study identifies PfGRP170 as an essential ER chaperone in Plasmodium falciparum, critical for asexual development and stress response.

CRISPR/Cas9 gene editing to make conditional mutants of the human malaria parasite Plasmodium falciparum

This paper describes a CRISPR/Cas9 method for generating conditional knockdown mutants in Plasmodium falciparum, enabling genetic manipulation of the malaria parasite.

The exported chaperone PfHsp70x is dispensable for the Plasmodium falciparum intraerythrocytic lifecycle

This study shows that PfHsp70x, the sole exported Hsp70 in P. falciparum, is not essential for parasite growth or protein export during the intraerythrocytic lifecycle.

PfClpC Is An Essential Clp Chaperone Required For Plastid Integrity And Clp Protease Stability In Plasmodium falciparum

This paper identifies PfClpC as an essential apicoplast-targeted chaperone in Plasmodium falciparum, showing its role in maintaining apicoplast integrity and parasite viability.