R. L. Moritz

Global Release of Translational Repression Across Plasmodiums Host-to-Vector Transmission Event

This study identifies the global release of translational repression in Plasmodium parasites during host-to-vector transmission using transcriptomics and proteomics.

Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research

The paper constructs a proteome resource, Borrelia PeptideAtlas, by integrating transcriptomic and proteomic data from multiple B. burgdorferi isolates to identify common proteins across infective strains.

Vacuum Insulated Probe Heated ElectroSpray Ionization source (VIP-HESI) enhances micro flow rate chromatography signals in the Bruker timsTOF mass spectrometer

The paper introduces VIP-HESI, a new electrospray source that enhances micro-flow rate chromatography signals and improves protein detection and quantification in mass spectrometry.

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

Plasmodium GPI-Anchored Micronemal Antigen is essential for parasite transmission through the mosquito host

This study shows that GAMA is essential for Plasmodium sporozoite motility, egress from oocysts, and invasion of the vertebrate host, with distinct roles in each process.

Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry.

The paper introduces Magnum, an algorithm for identifying drug-protein adducts, and Limelight, a tool for analyzing and visualizing adduct data, validated with CYP3A4 examples.

Plasmodium falciparum Calcium Dependent Protein Kinase 4 is critical for male gametogenesis and transmission to the mosquito vector

This study shows that PfCDPK4 is essential for male gametogenesis in Plasmodium falciparum, affecting exflagellation and parasite transmission to mosquitoes.

A wide-ranging Pseudomonas aeruginosa PeptideAtlas build: a useful proteomic resource for a versatile pathogen.

The paper builds a comprehensive Pseudomonas aeruginosa PeptideAtlas with high proteome coverage, providing a valuable resource for proteomic studies of this pathogen.

A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasites

This study identifies a druggable oxidative folding pathway in the ER of P. falciparum, showing that PfPDI8 is essential and sensitive to small molecule inhibition.

Platelet Derived Growth Factor Receptor β (PDGFRβ) is a Host Receptor for the human malaria parasite adhesin TRAP

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

Microvasculopathy, Luminal Calcification and Premature Aging in Fetuin-A Deficient Mice

This study shows fetuin-A deficiency leads to microvascular calcification and premature aging in mice, associated with thrombosis and fibrosis rather than osteochondrogenic differentiation.

Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

This study identifies two waves of translational repression in malaria sporozoite maturation using transcriptomic and proteomic data from Plasmodium species.

Proteomic Analysis of Plasmodium Merosomes: The Link Between Liver and Blood Stages in Malaria

This paper presents the first proteomic analysis of merosomes in Plasmodium berghei, identifying 1879 proteins and highlighting shared and unique features with blood stage proteomes.

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.

Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.