Author

M. R. Hoopmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. L. Moritz· 4 shared A. D. Leavitt· 1 shared A. M. Vaughan· 1 shared A. Naik· 1 shared A. P. Wiita· 1 shared A. Sinz· 1 shared A. Villegas· 1 shared A. Zelter· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

R. L. Moritz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

K. Mandal, G. Wicaksono, C. Yu, J. J. Adams, M. R. Hoopmann, W. C. Temple, B. P. Escobar, M. Gorelik, C. H. Ihling, M. A. Nix, A. Naik, E. Ramos, C. Kasap, V. Steri, J. A. C. Serrano, , A. P. Wiita

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

bioRxiv · Oct 10, 2022 · PreprintCancer Biology

Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry.

M. Riffle, M. R. Hoopmann, D. Jaschob, G. Zhong, R. L. Moritz, M. J. MacCoss, T. N. Davis, N. Isoherranen, A. Zelter

The paper introduces Magnum, an algorithm for identifying drug-protein adducts, and Limelight, a tool for analyzing and visualizing adduct data, validated with CYP3A4 examples.

bioRxiv · Jun 24, 2021Pharmacology & Toxicology

Plasmodium falciparum Calcium Dependent Protein Kinase 4 is critical for male gametogenesis and transmission to the mosquito vector

S. KUMAR, M. T. Haile, M. R. Hoopmann, L. T. Tran, S. A. Michaels, S. R. Morrone, K. K. Ojo, L. M. Reynolds, U. Kusebauch, A. M. Vaughan, R. L. Moritz, S. H. I. Kappe, K. E. Swearingen

This study shows that PfCDPK4 is essential for male gametogenesis in Plasmodium falciparum, affecting exflagellation and parasite transmission to mosquitoes.

bioRxiv · Jun 6, 2021Microbiology

A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasites

D. W. Cobb, H. M. Kudyba, A. Villegas, M. R. Hoopmann, R. Baptista, B. Bruton, M. Krakowiak, R. L. Moritz, V. Muralidharan

This study identifies a druggable oxidative folding pathway in the ER of P. falciparum, showing that PfPDI8 is essential and sensitive to small molecule inhibition.

bioRxiv · May 13, 2020Microbiology