K. Hristova

Utility of FRET in studies of membrane protein oligomerization: the concept of the effective dissociation constant

This paper introduces an effective dissociation constant derived from FRET measurements to quantify membrane receptor oligomerization and activity.

Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding

The paper quantifies ligand and mutation-induced bias in EGFR phosphorylation directly after ligand binding, showing that both factors influence RTK signaling without feedback loop contributions.

The efficacy of EphA2 tyrosine phosphorylation increases with EphA2 oligomer size

This study investigates the relationship between EphA2 oligomer size and signaling efficacy, finding a correlation between mean oligomer size and tyrosine phosphorylation.

Plasticity of transmembrane helix interactions in EphA2 dimers and oligomers

The paper investigates how EphA2 transmembrane helix mutations affect receptor-receptor interactions using FRET and FIF, finding plasticity in dimer interfaces rather than a binary switch between active/inactive states.

Ligand bias underlies differential signaling of multiple FGFs via FGFR1

The paper quantifies differential signaling of FGF4, FGF8, and FGF9 through FGFR1, revealing ligand bias and conformational differences in receptor dimers.

Effect of reversible osmotic stress on live cell plasma membranes, probed via Laurdan general polarization measurements

The paper investigates how osmotic stress affects live cell plasma membranes using Laurdan, finding increased generalized polarization (GP) in cells, opposite to lipid bilayers.

Direct quantification of ligand-induced lipid and protein microdomains with distinctive signaling properties

The paper directly observes ligand-induced GM1 and EphA2 microdomains in live cells and shows differential EphA2 signaling in these domains.

Neurotrophin signaling is modulated by specific transmembrane domain interactions

The paper identifies and characterizes the direct interaction between TrkA and p75 through their transmembrane domains, showing its role in TrkA activation and cell differentiation.

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

This study identifies how HHV-8 uses molecular mimicry of ephrin ligands to bind EphA2, triggering signaling that facilitates viral entry and cytoskeleton remodeling.

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo

This study demonstrates that melittin, a bee venom peptide, can reversibly open the blood-brain barrier in vitro and in vivo, enabling therapeutic delivery while maintaining neurological safety.

Allosteric Regulation of the EphA2 Receptor Intracellular Region by Serine/Threonine Kinases

This study reveals two allosteric mechanisms by which serine/threonine phosphorylation of the EphA2 linker regulates its non-canonical signaling, providing insights into its role in cancer.

Ligand-independent EGFR oligomers do not rely on the active state asymmetric kinase dimer

The paper investigates ligand-independent EGFR oligomers, finding they do not require the active state asymmetric kinase dimer interface and have distinct structural properties.