Author

E. B. Pasquale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. Hristova· 4 shared D. Wirth· 2 shared W. C. Wimley· 2 shared B. C. Lechtenberg· 1 shared D. McKenzie· 1 shared E. Ozdemir· 1 shared E. Zapata-Mercado· 1 shared G. Biener· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

K. Hristova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The efficacy of EphA2 tyrosine phosphorylation increases with EphA2 oligomer size

E. Zapata-Mercado, G. Biener, D. McKenzie, W. C. Wimley, E. B. Pasquale, V. Raicu, K. Hristova

This study investigates the relationship between EphA2 oligomer size and signaling efficacy, finding a correlation between mean oligomer size and tyrosine phosphorylation.

bioRxiv · Jun 7, 2022 · PreprintBiophysics

Plasticity of transmembrane helix interactions in EphA2 dimers and oligomers

D. Wirth, E. Ozdemir, W. C. Wimley, E. B. Pasquale, K. Hristova

The paper investigates how EphA2 transmembrane helix mutations affect receptor-receptor interactions using FRET and FIF, finding plasticity in dimer interfaces rather than a binary switch between active/inactive states.

bioRxiv · Jun 6, 2022 · PreprintBiophysics

Direct quantification of ligand-induced lipid and protein microdomains with distinctive signaling properties

D. Wirth, M. Paul, E. B. Pasquale, K. Hristova

The paper directly observes ligand-induced GM1 and EphA2 microdomains in live cells and shows differential EphA2 signaling in these domains.

bioRxiv · Sep 28, 2021Biophysics

Allosteric Regulation of the EphA2 Receptor Intracellular Region by Serine/Threonine Kinases

B. C. Lechtenberg, M. P. Gehring, T. P. Light, M. W. Matsumoto, K. Hristova, E. B. Pasquale

This study reveals two allosteric mechanisms by which serine/threonine phosphorylation of the EphA2 linker regulates its non-canonical signaling, providing insights into its role in cancer.

bioRxiv · Jan 28, 2021Biophysics