T. B. Huber

The integrated stress response/eIF2α pathway controls cytokine production in tissue-resident memory CD4+ T cells

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

This study determines the structure of the N-terminal didomain d1_d2 of THSD7A, revealing a non-canonical thrombospondin repeat fold with unique structural features contributing to its antigenicity.

Emergence and suppressive function of Tr1 cells in glomerulonephritis

This study identifies Tr1 cells in glomerulonephritis, showing their suppressive function and potential as therapeutic targets.

Transcriptional and clonal characterization of cytotoxic CD8+ T cells in crescentic glomerulonephritis

This study identifies clonally expanded cytotoxic CD8+ T cells in ANCA-associated cGN and shows their pathogenic role in kidney disease progression.

GM-CSF drives immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12

The paper identifies GM-CSF-producing T cells that drive glomerulonephritis by licensing monocyte-derived cells to produce MMP12, leading to renal tissue damage.

Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes

Loss of genome maintenance accelerates podocyte damage

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

Deep learning-based molecular morphometrics for kidney biopsies

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

Tripartite separation of glomerular cell-types and proteomes from reporter-free mice

This paper introduces a method to isolate and analyze glomerular cell types from reporter-free mice, revealing proteome differences and cell communication networks.