T. Koyama

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

A neuronal relay mediates muscle-adipose communication that drives systemic metabolic adaptation to high-sugar diets

The paper identifies a muscle-neuronal-fat tissue axis that modulates insulin secretion and adipocyte sensitivity to high-sugar diets, preventing hyperglycemia.

Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma

This study shows eosinophils reduce esophageal squamous cell carcinoma by releasing reactive oxygen species and inhibiting IL-17 pathways.

A gut-derived hormone switches dietary preference after mating in Drosophila

This study identifies a gut hormone in Drosophila that shifts dietary preference to protein-rich food after mating to support reproduction.

Biomechanical characteristics of scapula and glenohumeral movements during pitching motion in injury-prone college baseball pitchers

This study compares biomechanical differences in scapular and glenohumeral movements between injury-prone and healthy college baseball pitchers during pitching, finding greater horizontal abduction and less scapular internal rotation in injury-prone pitchers.

Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

This study uses single-cell RNA sequencing to identify nine hemocyte subpopulations in shrimp and their differentiation pathways.

The gut hormone Allatostatin C regulates food intake and metabolic homeostasis under nutrient stress

A Unique Renal Architecture in Tribolium castaneum Informs the Evolutionary Origins of Systemic Osmoregulation in Beetles

This paper identifies a unique renal architecture in beetles that uses diuretic hormones to regulate osmotic balance, revealing evolutionary adaptations for water stress resistance.

A nutrient-responsive hormonal circuit controls energy and water homeostasis in Drosophila

This study identifies a hormonal circuit in Drosophila that regulates energy and water homeostasis by modulating nutrient absorption, intestinal motility, and metabolic processes.

Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control

This study identifies LZTR1 (night owl) and its interaction with Nf1 in regulating GABAergic sleep control, linking them to schizophrenia and 22q11.2 deletion syndrome.