Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis
A. Boumaza, L. Gay, S. Mezouar, A. B. Diallo, M. Michel, B. Desnues, D. Raoult, B. LA SCOLA, P. Halfon, J. Vitte, D. Olive, J.-L. Mege
This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.
bioRxiv · Sep 17, 2020Immunology