Author

B. La Scola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 13 Immunology· 2 Biochemistry· 1 Evolutionary Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 16 Research Focus:host-pathogen & immune response· 8 Organism:human· 7 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Assay:DNA methylation· 3 Research Focus:drug response / drug discovery· 3 Assay:metagenomics· 3

Frequent Co-Authors

P. Colson· 10 shared D. Raoult· 8 shared A. Levasseur· 5 shared E. Chabriere· 4 shared J.-P. Baudoin· 4 shared C. Boschi· 3 shared J. Y. Bou Khalil· 3 shared J.-L. Mege· 3 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

10 shared papersMicrobiology

P. Colson

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Author profile →

18 papers

Recent·Most cited

Resuscitating Sleeping Beauties: reviving a six-hundred-year-old amoeba and endosymbiont.

I. Hasni, M. L. Tall, M. Le Bailly, P. Colson, A. Levasseur, D. Raoult, B. La Scola, M. Drancourt

This study revives a 600-year-old Acanthamoeba castellanii strain and its endosymbiont from coprolites, revealing their genomic features and survival mechanisms.

bioRxiv · Sep 22, 2023 · PreprintMicrobiology

Role of SARS-CoV-2 mutations in the evolution of the COVID-19 pandemic

P. Colson, H. Chaudet, J. Delerce, P. Pontarotti, A. Levasseur, J. Fantini, B. La Scola, C. A. Devaux, D. Raoult

The paper analyzes SARS-CoV-2 mutations across 61,397 genomes to identify 'hyperfertile' mutations that spread widely, finding most did not predict new epidemic forms, with some in non-coding regions and stop codons.

bioRxiv · May 1, 2023Microbiology

SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects

C. Boschi, D. E. Scheim, A. Bancod, M. Millitello, M. Le Bideau, P. Colson, J. Fantini, B. La Scola

This study shows SARS-CoV-2 spike proteins from four lineages induce hemagglutination, with Omicron requiring lower concentrations, and ivermectin inhibits this effect, suggesting therapeutic and safety implications.

bioRxiv · Nov 24, 2022 · PreprintBiochemistry

Sequencing of Monkeypox virus from infected patients reveals viral genomes with APOBEC3-like editing, gene inactivation, and bacterial agents of skin superinfection

P. Colson, G. Penant, J. Delerce, C. Boschi, N. Wurtz, S. Branger, J.-C. Lagier, N. Cassir, H. Tissot-Dupont, M. Million, S. Aherfi, B. La Scola

This study sequenced Monkeypox virus genomes from infected patients, revealing APOBEC3-like editing, gene inactivation, and bacterial superinfections in lesions.

bioRxiv · Sep 26, 2022Microbiology

Vγ9Vδ2 T cells are potent inhibitors of SARS-CoV-2 replication and exert effector phenotypes in COVID-19 patients

L. Gay, M.-S. Rouviere, S. Mezouar, M. Richaud, L. Gorvel, E. Foucher, L. Madakamutil, B. La Scola, A. Menard, J. Allardet-Servent, P. Halfon, P. Frohna, C. Cano, J.-L. Mege, D. Olive

This paper investigates how SARS-CoV-2 affects Vγ9Vδ2 T cells in patients and shows that anti-BTN3A activation enhances their antiviral response.

bioRxiv · Apr 15, 2022 · PreprintImmunology

A giant virus genome is densely packaged by stable nucleosomes within virions

T. D. Bryson, P. De Ioannes, M. I. Valencia-Sanchez, J. G. Henikoff, P. B. Talbert, B. La Scola, K.-J. Armache, S. Henikoff

The paper shows that Marseillevirus uses fully wrapped nucleosomes to densely package its genome, differing from eukaryotic chromatin organization.

bioRxiv · Jan 15, 2022Evolutionary Biology

Omicron variant escapes therapeutic mAbs contrary to eight prior main VOC

C. Boschi, P. Colson, A. Bancod, V. Moal, B. La Scola

The paper shows that the Omicron variant escapes neutralization by authorized mAbs, unlike previous variants, highlighting the need for updated protective measures for immunocompromised patients.

bioRxiv · Jan 3, 2022 · PreprintMicrobiology

GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition

P. Halfon, E. Bestion, K. Zandi, J. Andreani, J.-P. Baudoin, B. LA SCOLA, J.-L. Mege, S. Mezouar, R. F. Schinazi

This study shows GNS561, an autophagy inhibitor, has strong antiviral effects against SARS-CoV-2, both alone and in combination with remdesivir.

bioRxiv · Oct 6, 2020Pathology

Tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: Is it still a virus?

S. Aherfi, D. BRAHIM BELHAOUARI, L. Pinault, J.-P. Baudoin, P. Decloquement, J. Abrahao, P. Colson, A. LEVASSEUR, D. C. Lamb, E. Chabriere, D. Raoult, B. LA SCOLA

This study identifies functional enzymes of the tricarboxylic acid cycle in Pandoravirus massiliensis, suggesting it may possess energy production capabilities and challenging traditional virus definitions.

bioRxiv · Sep 21, 2020Microbiology

Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis

A. Boumaza, L. Gay, S. Mezouar, A. B. Diallo, M. Michel, B. Desnues, D. Raoult, B. LA SCOLA, P. Halfon, J. Vitte, D. Olive, J.-L. Mege

This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.

bioRxiv · Sep 17, 2020Immunology

A mysterious 80 nm amoeba virus with a near-complete "ORFan genome" challenges the classification of DNA viruses

P. V. M. Boratto, G. P. Oliveira, T. B. Machado, A. C. S. P. Andrade, J.-P. Baudoin, T. Klose, F. Schulz, S. Azza, P. Decloquement, E. Chabriere, P. Colson, A. Levasseur, B. La Scola, J. S. Abrahao

The paper describes the discovery of Yaravirus, a new amoeba virus with a near-complete ORFan genome, challenging existing DNA virus classifications.

Proceedings of the National Academy of Sciences · Jun 29, 2020Peer-reviewedMicrobiology

High speed large scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled with high content screening

R. Francis, M. Le Bideau, P. Jardot, C. Grimaldier, D. Raoult, J. Y. Bou Khalil, B. La Scola

This paper presents a high-content screening method for rapid and automated isolation of SARS-CoV-2 from clinical samples, achieving comparable isolation rates to traditional methods but with faster results and reduced contamination risks.

bioRxiv · May 14, 2020Microbiology

Advantages and limits of metagenomic assembly and binning of a giant virus

F. Schulz, J. Adreani, R. Francis, J. Y. Bou Khalil, J. Lee, B. LA SCOLA, T. Woyke

This study evaluates genome-resolved metagenomics for recovering giant virus genomes, showing success at high spike-in levels but highlighting the underdetection of most giant viruses.

bioRxiv · Jan 10, 2020Microbiology

High Content Screening, a reliable system for Coxiella burnetii isolation from clinical samples

R. Francis, M. Mioulane, M. Le Bideau, M.-C. Mati, P.-E. Fournier, D. Raoult, J. Y. Bou Khalil, B. La Scola

This paper develops a high content screening (HCS) method for isolating Coxiella burnetii from clinical samples, showing higher sensitivity and efficiency compared to traditional shell-vial assays.

bioRxiv · Dec 17, 2019Microbiology

A metallo-beta-lactamase with both beta-lactamase and ribonuclease activity is linked with traduction in giant viruses

P. Colson, L. Pinault, S. Azza, N. Armstrong, E. Chabriere, B. La Scola, P. Pontarotti, D. Raoult

The paper identifies a metallo-beta-lactamase with dual beta-lactamase and ribonuclease activity in a giant virus and shows its RNase activity is not inhibited by common inhibitors.

bioRxiv · Oct 28, 2019 · PreprintMicrobiology

Evidence of a cellulosic layer in Pandoravirus tegument and the mystery of the genetic support of its biosynthesis

D. BRAHIM BELHAOUARI, J.-P. BAUDOIN, F. GNANKOU, F. DI PINTO, P. Colson, S. Aherfi, B. LA SCOLA

This study investigates the composition of the Pandoravirus tegument, finding a cellulose-like layer and hypothesizing its synthesis may involve the host amoeba's machinery rather than viral genes.

bioRxiv · Oct 5, 2019 · PreprintMicrobiology

First evidence of host range expansion in virophages and its potential impact on giant viruses and host cells

S. Mougari, N. Chelkha, D. Sahmi-Bounsiar, F. Di Pinto, P. Colson, J. Abrahao, B. La Scola

The paper shows a virophage can expand its host range to new giant viruses, impacting giant virus production and host cell survival.

bioRxiv · Sep 24, 2019 · PreprintMicrobiology

Transfer of CRISPR-like activity of MIMIVIRE into Bacteria

S. Azza, B. La Scola, A. Levasseur, P. Perrin, E. Chabriere, D. Raoult

The paper transfers the MIMIVIRE defence system from Mimiviruses to E. coli to eliminate a plasmid by targeting tetracycline resistance sequences.

bioRxiv · Jul 11, 2019 · PreprintMicrobiology