Author

J.-L. Mege

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Mezouar· 5 shared B. La Scola· 3 shared C. A. Devaux· 3 shared L. Gay· 3 shared P. Halfon· 3 shared A. B. Diallo· 2 shared D. Olive· 2 shared I. Omar Osman· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersImmunology

S. Mezouar

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Preferential apical infection of intestinal cell monolayers by SARS-CoV-2 is associated with damage to cellular barrier integrity: Implications for the physiopathology of COVID-19

G. Clemence, A. Jeffrey, A. Jonatane, J.-L. Mege, I. Omar Osman, C. A. Devaux

This study shows SARS-CoV-2 preferentially infects the apical side of intestinal cell monolayers, causing barrier damage and potential systemic spread.

bioRxiv · Jan 8, 2024 · PreprintMicrobiology

Identification and characterization of an HtrA sheddase produced by Coxiella burnetii

I. O. OSMAN, A. Caputo, L. PINAULT, J.-L. Mege, A. LEVASSEUR, C. A. Devaux

The paper identifies and characterizes an HtrA sheddase produced by Coxiella burnetii and shows its role in cleaving E-cadherin, inducing M2 polarization, and enhancing bacterial replication.

bioRxiv · Jan 26, 2023 · PreprintMicrobiology

Modulation of the E-cadherin in human cells infected in vitro with Coxiella burnetii

I. OMAR OSMAN, S. Mezouar, D. BRAHIM BELHAOUARI, J.-L. MEGE, C. A. Devaux

This study shows that live Coxiella burnetii infection reduces membrane-bound E-cadherin and alters the E-cadherin/{beta}-catenin signaling pathway in BeWo cells.

bioRxiv · Dec 8, 2022 · PreprintMicrobiology

Vγ9Vδ2 T cells are potent inhibitors of SARS-CoV-2 replication and exert effector phenotypes in COVID-19 patients

L. Gay, M.-S. Rouviere, S. Mezouar, M. Richaud, L. Gorvel, E. Foucher, L. Madakamutil, B. La Scola, A. Menard, J. Allardet-Servent, P. Halfon, P. Frohna, C. Cano, J.-L. Mege, D. Olive

This paper investigates how SARS-CoV-2 affects Vγ9Vδ2 T cells in patients and shows that anti-BTN3A activation enhances their antiviral response.

bioRxiv · Apr 15, 2022 · PreprintImmunology

GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition

P. Halfon, E. Bestion, K. Zandi, J. Andreani, J.-P. Baudoin, B. LA SCOLA, J.-L. Mege, S. Mezouar, R. F. Schinazi

This study shows GNS561, an autophagy inhibitor, has strong antiviral effects against SARS-CoV-2, both alone and in combination with remdesivir.

bioRxiv · Oct 6, 2020Pathology

Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis

A. Boumaza, L. Gay, S. Mezouar, A. B. Diallo, M. Michel, B. Desnues, D. Raoult, B. LA SCOLA, P. Halfon, J. Vitte, D. Olive, J.-L. Mege

This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.

bioRxiv · Sep 17, 2020Immunology

Daytime variation in SARS-CoV-2 infection and cytokine production

A. B. Diallo, L. Gay, B. Coiffard, M. Leone, S. Mezouar, J.-L. Mege

This study shows that SARS-CoV-2 infection and cytokine production in human monocytes vary with the time of day, suggesting circadian rhythm influences viral progression and immune response.

bioRxiv · Sep 9, 2020Immunology