This study shows that live Coxiella burnetii infection reduces membrane-bound E-cadherin and alters the E-cadherin/{beta}-catenin signaling pathway in BeWo cells.

bioRxiv · Dec 8, 2022 · PreprintMicrobiology

Vγ9Vδ2 T cells are potent inhibitors of SARS-CoV-2 replication and exert effector phenotypes in COVID-19 patients

L. Gay, M.-S. Rouviere, S. Mezouar, M. Richaud, L. Gorvel, E. Foucher, L. Madakamutil, B. La Scola, A. Menard, J. Allardet-Servent, P. Halfon, P. Frohna, C. Cano, J.-L. Mege, D. Olive

This paper investigates how SARS-CoV-2 affects Vγ9Vδ2 T cells in patients and shows that anti-BTN3A activation enhances their antiviral response.

bioRxiv · Apr 15, 2022 · PreprintImmunology

GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer

S. Brun, J.-M. Pascussi, E. P. Gifu, E. Bestion, Z. Macek-Jilkova, G. Wang, F. Bassissi, S. Mezouar, J. Courcamberck, P. Merle, T. Decaens, J. Pannequin, P. Halfon, C. Caron de Fromentel

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

bioRxiv · Dec 21, 2020Cancer Biology

Stool serology: development of a non-invasive immunological method for the detection of Enterovirus-specific antibodies in Congo gorilla faeces

Y. Sereme, S. M. Zarza, H. Medkour, I. Amona, F. Fenollar, J. Akiana, S. Mezouar, N. Orain, J. Vitte, B. Davoust, D. Raoult, O. Mediannikov

The paper develops a non-invasive method to detect Enterovirus-specific antibodies in gorilla faeces, finding specific antibodies in 4/16 gorilla samples and 2/3 human samples.

bioRxiv · Nov 28, 2020Microbiology

GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition

P. Halfon, E. Bestion, K. Zandi, J. Andreani, J.-P. Baudoin, B. LA SCOLA, J.-L. Mege, S. Mezouar, R. F. Schinazi

This study shows GNS561, an autophagy inhibitor, has strong antiviral effects against SARS-CoV-2, both alone and in combination with remdesivir.

bioRxiv · Oct 6, 2020Pathology

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

S. BRUN, E. Raymond, F. Bassissi, Z. M. Jilkova, S. Mezouar, M. Rachid, M. Novello, J. Tracz, A. Hamai, G. Lalmanach, L. Vanderlynden, E. Bestion, R. Legouffe, J. Stauber, T. Schubert, , P. Halfon

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.

bioRxiv · Sep 30, 2020Cancer Biology

Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis

A. Boumaza, L. Gay, S. Mezouar, A. B. Diallo, M. Michel, B. Desnues, D. Raoult, B. LA SCOLA, P. Halfon, J. Vitte, D. Olive, J.-L. Mege

This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.

bioRxiv · Sep 17, 2020Immunology

Daytime variation in SARS-CoV-2 infection and cytokine production

A. B. Diallo, L. Gay, B. Coiffard, M. Leone, S. Mezouar, J.-L. Mege

This study shows that SARS-CoV-2 infection and cytokine production in human monocytes vary with the time of day, suggesting circadian rhythm influences viral progression and immune response.

bioRxiv · Sep 9, 2020Immunology