Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses
S. Xu, O. Chaudhary, P. Rodriguez-Morales, X. Sun, R. Zappasodi, Z. Xu, A. F. M. Pinto, A. Williams, D. Chen, J. S. Low, Y. Farsakoglu, W. Tang, H. Wang, S. K. Varanasi, B. McDonald, , S. M. Kaech
This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.
bioRxiv · Sep 3, 2020Immunology