Author

M. Ciofani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. Park· 2 shared J. Heitman· 2 shared J. Hong· 2 shared M. J. Hoy· 2 shared P. R. Juvvadi· 2 shared A. Floyd Averette· 1 shared A. Mihai· 1 shared A. Rivera· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

E. Park

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

E protein control of NKgammadeltaT cell development through both generation and function of the stereotypic Vgamma1Vdelta6.3 TCR

D. L. Wiest, A. Mihai, S.-Y. Lee, S. Shinton, M. I. Parker, A. V. Contreras, B. Zhang, M. Rhodes, R. L. Dunbrack, J. C. Zuniga-Pflucker, M. Ciofani, Y. Zhuang

This study shows that Id3 deficiency affects the development of gamma delta T cell subsets by regulating the generation and function of the Vgamma1Vdelta6.3 TCR.

bioRxiv · Jan 4, 2024 · PreprintImmunology

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

A. Rivera, W. Lim, E. Park, P. A. Dome, M. J. Hoy, I. Spasojevic, S. Sun, A. Floyd Averette, S. Pina-Oviedo, P. R. Juvvadi, W. J. Steinbach, M. Ciofani, J. Hong, J. Heitman

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

bioRxiv · Jun 5, 2023Microbiology

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

M. J. Hoy, E. Park, H. Lee, W. Y. Lim, D. C. Cole, N. D. DeBouver, B. G. Bobay, P. G. Pierce, D. Fox, M. Ciofani, P. R. Juvvadi, W. Steinbach, J. Hong, J. Heitman

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

bioRxiv · Mar 25, 2022Microbiology

JunB controls intestinal effector programs in regulatory T cells

J. D. Wheaton, M. Ciofani

This study identifies JunB as a critical regulator of intestinal Treg effector programs, showing its role in maintaining specific Treg subsets and effector functions.

bioRxiv · Nov 13, 2019Immunology