Author

M. J. Hoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

E. Park· 2 shared J. Heitman· 2 shared J. Hong· 2 shared M. Ciofani· 2 shared P. R. Juvvadi· 2 shared A. Floyd Averette· 1 shared A. Rivera· 1 shared B. G. Bobay· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMicrobiology

E. Park

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2 papers

Recent·Most cited

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

A. Rivera, W. Lim, E. Park, P. A. Dome, M. J. Hoy, I. Spasojevic, S. Sun, A. Floyd Averette, S. Pina-Oviedo, P. R. Juvvadi, W. J. Steinbach, M. Ciofani, J. Hong, J. Heitman

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

bioRxiv · Jun 5, 2023Microbiology

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

M. J. Hoy, E. Park, H. Lee, W. Y. Lim, D. C. Cole, N. D. DeBouver, B. G. Bobay, P. G. Pierce, D. Fox, M. Ciofani, P. R. Juvvadi, W. Steinbach, J. Hong, J. Heitman

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

bioRxiv · Mar 25, 2022Microbiology