The splicing regulator Prp31 prevents retinal degeneration in Drosophila by regulating Rhodopsin levels
Malte Lehmann, Sarita Hebbar, B. Grygo Sarah, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust
This study shows that mutations in the splicing factor Prp31 in Drosophila cause light-dependent retinal degeneration by increasing rhodopsin 1 accumulation, which can be mitigated by reducing rhodopsin levels.
bioRxiv · Aug 13, 2018 · PreprintGenetics