Author

Malte Lehmann

Max Planck Institute of Molecular Cell Biology and GeneticsORCID 0000-0002-3786-7375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Elisabeth KnustiD· 2 shared Sarita HebbariD· 2 shared Sylke WinkleriD· 2 shared Weihua Leng· 2 shared Andreas NitscheiD· 1 shared Anja Andrea KühliD· 1 shared B. Grygo Sarah· 1 shared Barbara Ingold‐Heppner· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Elisabeth KnustORCID

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3 papers

Recent·Most cited

Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients

Jenny Meinhardt, Josefine Radke, Carsten Dittmayer, Jonas Franz, Carolina Thomas, Ronja Mothes, Michael M. Laue, Julia A. Schneider, Sebastian Brünink, Selina Greuel, Malte Lehmann, Olga Hassan, Tom Aschman, Elisa Schumann, Robert Lorenz Chua, , Frank L. Heppner

The paper investigates SARS-CoV-2 entry into the CNS via the olfactory mucosa in COVID-19 patients and demonstrates neurotropism and cerebral thromboembolism.

Nature Neuroscience · Nov 30, 2020Peer-reviewedNeuroscience

The splicing regulator Prp31 prevents retinal degeneration in Drosophila by regulating Rhodopsin levels

Malte Lehmann, Sarita Hebbar, B. Grygo Sarah, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust

This study shows that mutations in the splicing factor Prp31 in Drosophila cause light-dependent retinal degeneration by increasing rhodopsin 1 accumulation, which can be mitigated by reducing rhodopsin levels.

bioRxiv · Aug 13, 2018 · PreprintGenetics

Mutations in the Drosophila splicing regulator Prp31 as a model for Retinitis pigmentosa 11

Malte Lehmann, Sarita Hebbar, Holger Brandl, Weihua Leng, Naharajan Lakshmanaperumal, Sylke Winkler, Elisabeth Knust

This study uses a Drosophila model to investigate the effects of Prp31 mutations, showing light-induced retinal degeneration linked to oxidative stress and splicing defects.

bioRxiv · Jun 9, 2017 · PreprintGenetics