Weihua Leng

Visualizing sub-organellar lipid distribution using correlative light and electron microscopy

This paper introduces a correlative light and electron microscopy workflow to quantify lipid densities in membrane nanodomains and finds sphingomyelin partitions into specific endosomal structures.

Cell free expression in proteinosomes prepared from native protein-PNIPAAm conjugates

This study demonstrates cell-free transcription and translation in proteinosomes made from native protein-polymer conjugates, showing enhanced stability and expression compared to traditional methods.

A local insulin reservoir ensures developmental progression in condition of nutrient shortage in Drosophila

The paper shows that Dilps are stored in the Corpora Cardiaca and released during nutrient shortage to activate IIS in the prothoracic gland, accelerating pupal development.

The splicing regulator Prp31 prevents retinal degeneration in Drosophila by regulating Rhodopsin levels

This study shows that mutations in the splicing factor Prp31 in Drosophila cause light-dependent retinal degeneration by increasing rhodopsin 1 accumulation, which can be mitigated by reducing rhodopsin levels.

Mutations in the Drosophila splicing regulator Prp31 as a model for Retinitis pigmentosa 11

This study uses a Drosophila model to investigate the effects of Prp31 mutations, showing light-induced retinal degeneration linked to oxidative stress and splicing defects.