Sylke Winkler

The paper investigates sex determination in Taxus baccata and finds no evidence for a genetic sex-determining region, suggesting a non-genetic mechanism.

The paper presents a high-quality genome assembly for the Seabra's wing-gland bat, Cistugo seabrae.

This study integrates genomics and transcriptomics to identify molecular changes in vampire bats adapted to blood-feeding, revealing shifts in gene expression and function across multiple biological pathways.

This study presents seven reference genomes of side-necked turtles, revealing chromosomal dynamics, sex chromosome evolution, and molecular mechanisms underlying skeletal innovation and cancer resistance.

The paper identifies convergent and lineage-specific genomic changes in sugar-feeding birds through genome and transcriptome analyses, revealing adaptive mechanisms in metabolic pathways.

The paper presents two new high-quality genomes from the cockroach genus Cryptocercus to study adaptations to xylophagy and subsociality, finding relaxed selection and positive selection in energy production pathways.

This study presents chromosome-level genomes for sloths and anteaters, revealing retrocopy formation and domestication as key drivers of xenarthran genome evolution and physiological specializations.

This study analyzes repetitive DNAs in eleven Hydnoraceae genomes, revealing distinct repeat profiles between genera and suggesting their role in genome evolution.

The paper demonstrates long-read sequencing and genome assembly of ethanol-preserved samples, including challenging organisms like the maned sloth, achieving a 3.1 Gb assembly.

This paper presents a chromosome-level, haplotype-resolved genome assembly for the Eurasian minnow, revealing haplotype diversity and structural variations.

This paper presents chromosome-scale genome assemblies and regulatory element annotations for planarians, revealing conservation of regulatory regions despite rapid structural divergence.

The paper presents genome assemblies for three Platynereis species to support comparative genomic studies and explore their biology.

The paper analyzes genomes of leatherback and green turtles to identify gene family expansions and demographic differences that may influence their ecological adaptations and conservation status.

This study introduces modern human-specific amino acid substitutions into mice and human brain organoids, showing improved chromosome segregation fidelity in modern humans compared to Neandertals.

The paper assembles and compares chromosome-level genomes of two Hyles hawkmoth species, revealing conserved synteny and chromosomal rearrangements.

The paper identifies a new nematode species from Siberian permafrost and shows it shares cryptobiosis mechanisms with C. elegans dauer larvae.

The paper benchmarks DNA preservation methods for long-read and long-range sequencing across vertebrates, finding that optimal methods vary by taxa, tissue, and application.

This study shows that lrrk2 knockout in zebrafish causes dopamine and serotonin catabolism changes, reduced cell proliferation, and impaired neuronal regeneration.

The paper develops a pipeline for mitochondrial genome assembly and identifies errors and novel duplications in reference mitogenomes.

The paper summarizes methods and lessons from assembling 16 vertebrate genomes, highlights the importance of long-read sequencing, and introduces the Vertebrate Genomes Project to generate complete reference genomes for all vertebrate species.

The paper generates six reference-quality bat genomes, identifies genomic adaptations related to echolocation, immunity, and viral tolerance, and reveals regulatory elements contributing to bat traits.

This study shows that mutations in the splicing factor Prp31 in Drosophila cause light-dependent retinal degeneration by increasing rhodopsin 1 accumulation, which can be mitigated by reducing rhodopsin levels.

The paper identifies human-specific genes preferentially expressed in fetal neocortex progenitors and shows they have distinct cell-type specificity compared to ancestral paralogs.

This study uses a Drosophila model to investigate the effects of Prp31 mutations, showing light-induced retinal degeneration linked to oxidative stress and splicing defects.