Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
A. Maker, M. Bolejack, L. Schecterson, B. Hammerson, J. Abendroth, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner
The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.
bioRxiv · Mar 21, 2022Biochemistry