Author

T. E. Edwards

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Organism:human· 3 Assay:protein structure· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Maker· 2 shared B. M. Gumbiner· 2 shared B. Staker· 2 shared J. Abendroth· 2 shared P. J. Myler· 2 shared A. B. Suryawanshi· 1 shared A. Deshmukh· 1 shared A. Gustchina· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Maker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

A. Maker, M. Bolejack, L. Schecterson, B. Hammerson, J. Abendroth, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

bioRxiv · Mar 21, 2022Biochemistry

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

B. Xie, A. Maker, A. V. Priest, D. M. Dranow, J. N. Phan, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner, S. Sivasankar

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

bioRxiv · Mar 6, 2022Biophysics

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

p. kesari, A. Deshmukh, N. Pahelkar, A. B. Suryawanshi, I. Rathore, V. Mishra, J. H. Dupuis, H. Xiao, A. Gustchina, J. Abendroth, M. Labaied, R. Y. Yada, A. Wlodawer, T. E. Edwards, D. D. Lorimer, P. Bhaumik

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

bioRxiv · Sep 24, 2021Biophysics

New Structural Insights into the Function of the Catalytically Active Human Taspase1

N. Nagaratnam, S. Delker, R. Jernigan, T. E. Edwards, J. Snider, D. Thifault, D. Williams, B. L. Nannenga, M. Stofega, L. Sambucetti, J. Hsieh, A. J. Flint, P. Fromme, J. M. Martin-Garcia

This study determines the crystal structure of catalytically active human Taspase1 and identifies a long helical domain essential for its enzymatic activity, suggesting it as a potential target for anticancer therapeutics.

bioRxiv · Nov 26, 2020Biochemistry