A. Maker

High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.

This study evaluates the Gatan Alpine detector at 100-200 keV for cryo-EM, showing improved resolution and performance compared to the Gatan K3.

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

The paper investigates how HIV-1 envelope glycan networks affect the formation and stability of broadly neutralizing antibody epitopes, showing their importance in immunogen design.

KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus Scrofa Pigs

This study creates a transgenic pig model of pancreatic ductal adenocarcinoma by expressing KRASG12D and TP53R167H, showing tumor development in vivo and providing a new large animal model for research.