P. J. Myler

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites

The paper provides high-quality genome assemblies and gene annotations for 13 Leishmania and related species to study the origins of parasitism.

A divergent protein kinase A in the human pathogen Leishmania is associated with cell cortex microtubules and controls cell shape

This paper identifies a novel PKA regulatory subunit in Leishmania that localizes to microtubules and controls promastigote shape by tethering the catalytic subunit to the cell cortex.

The hunger games: sensing host arginine is essential for Leishmania parasite virulence

This study shows that Leishmania parasites use an arginine sensing mechanism to enhance virulence by up-regulating arginine transport during infection.