Author

B. M. Gumbiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Maker· 2 shared B. Staker· 2 shared B. Xie· 2 shared L. Schecterson· 2 shared P. J. Myler· 2 shared S. Sivasankar· 2 shared T. E. Edwards· 2 shared A. J. H. Cabrera· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersBiochemistry

A. Maker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Strengthening E-cadherin adhesion via antibody mediated binding stabilization.

B. Xie, S. Xu, L. Schecterson, B. M. Gumbiner, S. Sivasankar

This study identifies how the monoclonal antibody 66E8 stabilizes E-cadherin adhesion by stabilizing the strand-swap dimer conformation through electrostatic interactions.

bioRxiv · Jul 4, 2023Biophysics

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

A. Maker, M. Bolejack, L. Schecterson, B. Hammerson, J. Abendroth, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

bioRxiv · Mar 21, 2022Biochemistry

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

B. Xie, A. Maker, A. V. Priest, D. M. Dranow, J. N. Phan, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner, S. Sivasankar

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

bioRxiv · Mar 6, 2022Biophysics

The roles of distinct Ca2+ signaling mediated by Piezo and inositol triphosphate receptor (IP3R) in the remodeling of E-cadherin during cell dissemination

A. J. H. Cabrera, B. M. Gumbiner, Y. V. Kwon

This study shows that E-cadherin remodeling during cell dissemination in Drosophila is controlled by two distinct Ca2+ signaling pathways mediated by IP3R and Piezo.

bioRxiv · Nov 10, 2021 · PreprintCell Biology