Deglutarylation of GCDH by SIRT5 controls lysine metabolism in mice
D. P. Bhatt, C. A. Mills, K. A. Anderson, B. J. Henriques, T. G. Lucas, S. Francisco, J. Liu, O. R. Ilkayeva, A. E. Adams, S. R. Kulkarni, D. S. Backos, P. A. Grimsrud, C. M. Gomes, M. D. Hirschey
This study identifies glutarylation of GCDH by glutaryl-CoA and shows SIRT5 deglutarylates GCDH, restoring its function and regulating lysine metabolism in mice.
bioRxiv · Jun 28, 2020 · PreprintBiochemistry