Author

B. L. LeSavage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. E. Gilchrist· 1 shared A. R. Smith· 1 shared B. A. Krajina· 1 shared C. Curtis· 1 shared C. J. Kuo· 1 shared K. C. Klett· 1 shared K. Karagyozova· 1 shared K. Karlsson· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. E. Gilchrist

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1 paper

Recent·Most cited

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

B. L. LeSavage, A. E. Gilchrist, B. A. Krajina, K. Karlsson, A. R. Smith, K. Karagyozova, K. C. Klett, C. Curtis, C. J. Kuo, S. C. Heilshorn

This study shows that high stiffness engineered matrices induce chemoresistance in pancreatic cancer organoids through hyaluronan mechanosignaling and a plastic cancer stem cell phenotype.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology