Author

S. C. Heilshorn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 3 Cell Biology· 2 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:rat· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. Enejder· 2 shared A. Hargil· 2 shared G. Peltz· 2 shared M. E. Hefferon· 2 shared M. J. Kratochvil· 2 shared M. Wang· 2 shared P. K. Johansson· 2 shared P. L. Bollyky· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

A. Enejder

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding

Q. Chen, P. Cai, T. H. W. Chang, E. Burgener, M. J. Kratochvil, A. Gupta, A. Hargil, P. R. Secor, J. E. Nielsen, A. E. Barron, C. Milla, S. C. Heilshorn, A. J. Spakowitz, P. L. Bollyky

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

bioRxiv · Mar 10, 2024 · PreprintMicrobiology

Rapid assessment of changes in phage bioactivity using dynamic light scattering

T. Dharmaraj, M. J. Kratochvil, J. D. Pourtois, Q. Chen, M. Hajfathalian, A. Hargil, Y.-H. Lin, Z. R. Evans, A. Oromi-Bosch, J. D. Berry, R. McBride, N. L. Haddock, D. R. Holman, J. D. Van Belleghem, T. H. Chang, , P. L. Bollyky

This paper uses Dynamic Light Scattering to assess phage bioactivity changes over time and optimize storage conditions for clinical phage applications.

bioRxiv · Jul 2, 2023Biophysics

Custom-engineered hydrogels for delivery of human iPSC-derived neurons into the injured cervical spinal cord

V. M. Doulames, L. M. Marquardt, M. E. Hefferon, N. J. Baugh, R. A. Suhar, A. T. Wang, K. Dubbin, J. M. Weimann, T. D. Palmer, G. W. Plant, S. C. Heilshorn

This study develops a custom hydrogel for delivering human iPSC-derived neurons to injured cervical spinal cords, improving cell integration and sensorimotor function in rats.

bioRxiv · May 10, 2023Bioengineering

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

Y. Guan, Z. Fang, A. Hu, S. Roberts, M. Wang, W. Ren, P. K. Johansson, S. C. Heilshorn, A. Enejder, G. Peltz

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

bioRxiv · Apr 25, 2023 · PreprintCell Biology

Gelation of Uniform Interfacial Diffusant in Embedded 3D Printing

S. Shin, L. G. Brunel, B. Cai, D. Kilian, J. G. Roth, A. J. Seymour, S. C. Heilshorn

This paper introduces a 3D bioprinting method called GUIDE-3DP to create perfusable, branched vascular networks with precise control over geometry and vessel sizes.

bioRxiv · Apr 2, 2023Bioengineering

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

B. L. LeSavage, A. E. Gilchrist, B. A. Krajina, K. Karlsson, A. R. Smith, K. Karagyozova, K. C. Klett, C. Curtis, C. J. Kuo, S. C. Heilshorn

This study shows that high stiffness engineered matrices induce chemoresistance in pancreatic cancer organoids through hyaluronan mechanosignaling and a plastic cancer stem cell phenotype.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology

Hyaluronan and Elastin-Like Protein (HELP) Gels Significantly Improve Cargo Retention in the Myocardium

R. A. Suhar, V. M. Doulames, Y. Liu, M. E. Hefferon, O. Figueroa, H. Buabbas, S. C. Heilshorn

This study evaluates HELP gels as injectable carriers to improve cargo retention in the myocardium, showing better retention than Matrigel in rat models.

bioRxiv · Oct 24, 2021 · PreprintBioengineering

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

Y. GUAN, A. Enejder, M. Wang, Z. Fang, L. Cui, S.-Y. Chen, J. Wang, Y. Tan, M. Wu, X. Chen, P. K. Johansson, I. Osman, K. Kunimoto, P. Russo, S. C. Heilshorn, G. Peltz

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

Nature Communications · Oct 22, 2021Peer-reviewedCell Biology