Author

B. L. Levine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:CITE-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

E. J. Wherry· 2 shared F. D. Bushman· 2 shared G. M. Chen· 2 shared J. A. Fraietta· 2 shared J. J. Melenhorst· 2 shared N. V. Frey· 2 shared R. M. Young· 2 shared A. Chandra· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersImmunology

E. J. Wherry

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

A. J. Dimitri, A. E. Baxter, G. M. Chen, C. R. Hopkins, G. T. Rouin, H. Huang, W. Kong, C. H. Holliday, V. Wiebking, R. Bartoszek, S. Drury, K. Dalton, O. M. Koucky, Z. Chen, J. R. Giles, , J. A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

bioRxiv · Mar 29, 2024Immunology

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

J. J. Melenhorst, G. M. Chen, M. Wang, D. . L. Porter, P. Gao, S. Bandyopadhyay, I. Pruteanu-Malinici, C. L. Nobles, S. Maji, N. V. Frey, S. I. Gill, L. Tian, I. Kulikovskaya, M. Gupta, M. M. Davis, , C. H. June

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

bioRxiv · May 7, 2021 · PreprintImmunology

Predicting T Cell Quality During Manufacturing Through an Artificial Intelligence-based Integrative Multi-Omics Analytical Platform

V. Y. Odeh-Couvertier, N. J. Dwarshuis, M. B. Colonna, B. L. Levine, A. S. Edison, T. Kotanchek, K. Roy, W. Torres-Garcia

The paper develops an AI-based platform to predict T cell quality during manufacturing using multi-omics data and identifies critical process parameters and quality attributes.

bioRxiv · May 5, 2021Bioengineering