W. Kong

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans

This study identifies ELO-6 expression as a predictor of longevity in isogenic C. elegans populations and shows its regulation by PQM-1.

The synergistic effects of plants and nitrogen on microbial hitchhiking

The paper investigates how plants and nitrogen fertilizer influence microbial hitchhiking, finding that their synergy affects soil microbiome composition and function depending on nitrogen levels.

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

Development of membrane-like pre-stem cells after released from tube-shaped niches

The paper identifies two membrane-like pre-stem progenitors that develop into c-kit-positive stem cell progenitors and multi-nucleated cells, challenging existing concepts of stem cell self-renewal and lineage origins.

The self-renewal procedures of mesenchymal stem cells in the blood

The paper identifies a multi-step self-renewal process for mesenchymal stem cells in mouse blood and human umbilical cord blood, involving niche structures and non-mitotic differentiation.

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

The PELOTA-HBS1 Complex Orchestrates mRNA Translation Surveillance and PDK1-mediated Plant Growth and Development

This study identifies the PELOTA-HBS1 complex's role in mRNA translation surveillance and PDK1-mediated plant growth by rescuing a pdk1 mutant in Arabidopsis.

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection

This study shows that KSHV modulates polyamine biosynthesis and eIF5A hypusination to promote viral infection and oncogenesis, identifying these pathways as therapeutic targets.

Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

A lipid code-dependent phosphoswitch directs PIN-mediated auxin efflux in Arabidopsis development

The paper identifies a lipid-dependent phosphorylation cascade involving PDK1 and D6PK that regulates PIN-mediated auxin efflux in Arabidopsis development.

Molecular changes in Mesembryanthemum crystallinum guard cells underlying the C3 to CAM transition

This study identifies transcriptomic changes in guard cells of M. crystallinum during salt-induced C3 to CAM transition, showing guard cells can undergo this shift.

Force inference predicts local and tissue-scale stress patterns in epithelia

This study validates force inference as a reliable method to predict force patterns in Drosophila epithelia by comparing it with laser ablation experiments.

Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection

This study investigates nasal immune responses in rainbow trout to Ichthyophthirius multifiliis infection, finding parasite-specific IgT production and B-cell proliferation in the nasal mucosa.

Preclinical Study: Sunitinib-suppressed MiR-452-5p Facilitates Renal Cancer Cell Invasion and Metastasis Through Modulating SMAD4/SMAD7/EMT Signals

This study identifies miR-452-5p as a key regulator of renal cancer metastasis, showing its upregulation and role in promoting invasion through SMAD4/SMAD7/EMT signaling.