L. Tian

An empirical evaluation of simulated gastrointestinal digestion platforms for use in plant breeding, using common bean (Phaseolus vulgaris L.) as a model

This study evaluates simulated digestion models to assess bioaccessible nutrient levels in common bean, finding dynamic models outperform static ones in predicting nutrient release.

Availability of an inflammatory macrophage niche drives phenotypic and functional alterations in Kupffer cells

The paper shows that blocking monocytes alone is insufficient to reduce LMAMs, as KCs can replenish them through proliferation or infiltration, and their reprogramming contributes to immunosuppression.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Global invasion history and genomic signatures of adaptation of a highly invasive lace bug

This study investigates the genomic basis of invasion in the sycamore lace bug, identifying adaptation signatures and invasion routes through genomic analysis.

Deciphering the Molecular Mechanism of Post-Acute Sequelae of COVID-19 through Comorbidity Network Analysis

This study analyzes longitudinal electronic health records to identify comorbidity patterns influenced by COVID-19 and their biological mechanisms through protein-protein interaction networks.

Sequence characterization of T, Bip, and Phbw demonstrates the role of MYB-bHLH-WD40 complexes and temperature in common bean seed color pattern formation

This study identifies mutations in MYB-bHLH-WD40 complex genes and shows temperature affects seed color patterns in common bean.

The colocatome as a spatial -omic reveals shared microenvironment features between tumour-stroma assembloids and lung cancer specimens

The paper introduces the colocatome, a spatial-omic framework, to compare microenvironment features between tumour-stroma assembloids and lung cancer specimens, finding that fibroblasts protect cancer cells from treatment by reorganizing cytoarchitecture.

Radiation-induced rescue effect on human breast carcinoma cells is regulated by macrophages

This study demonstrates that macrophage polarization modulates radiation-induced rescue effect (RIRE) in breast carcinoma cells, influencing radiotherapy efficacy.

Metabolism regulates muscle stem cell self-renewal by connecting the microenvironment and histone acetylation

The paper identifies how extracellular monosaccharide availability influences muscle stem cell self-renewal through histone acetylation and metabolic signaling.

Building methodological consensus to ensure rigor and reproducibility in zebrafish fertility research

This paper identifies the lack of methodological consensus in zebrafish fertility research and argues that standardized spawning parameters are needed to improve reproducibility in reproductive biology and toxicology.

Widespread readthrough events in plants reveal unprecedented plasticity of stop codons

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

A MAP kinase cascade broadly regulates development and virulence of Sclerotinia sclerotiorum and can be targeted by HIGS for disease control

This study identifies a conserved MAPK cascade in S. sclerotiorum essential for growth, development, and virulence, and demonstrates its targeting by HIGS reduces pathogen virulence.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

Distinct tumor architectures for metastatic colonization of the brain

This study compares the brain metastasis colonization strategies of triple-negative breast cancer and HER2+ breast cancer, revealing distinct tumor architectures and stromal interactions.

EDoF-Miniscope: pupil engineering for extended depth-of-field imaging in a fluorescence miniscope

The paper introduces EDoF-Miniscope, a fluorescence miniscope with extended depth-of-field imaging, achieving 2.8X depth extension and high-contrast signals in mouse brain samples.

Single-shot Volumetric Chemical Imaging by Mid- Infrared Photothermal Fourier Light Field Microscopy

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

This study examines how exercise affects stem cell compartments and immune cells in aging mice, identifying rejuvenating effects and transcriptomic changes.

Structure Insight into Photosystem I Octamer from Cyanobacteria

The paper isolates and characterizes two novel photosystem I supercomplexes from cyanobacteria, revealing the structure of the PSI octamer at near-atomic resolution.

A single nucleotide change in the polC DNA polymerase III in Clostridium thermocellum is sufficient to create a hypermutator phenotype

The paper introduces a C669Y mutation in polC of C. thermocellum, resulting in a 30-fold increase in mutation rate and a hypermutator phenotype.

Cytoplasmic tail truncation of SARS-CoV-2 Spike protein enhances titer of pseudotyped vectors but masks the effect of the D614G mutation

This study shows that truncating the SARS-CoV-2 Spike protein's cytoplasmic tail increases pseudovector titer but masks the D614G mutation's effect on Spike incorporation.

FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

TIR signaling promotes the interactions between EDS1/PAD4 and ADR1-L1 and oligomerization of ADR1-L1

This study shows TIR signaling enhances the interaction between EDS1/PAD4 and ADR1-L1 and promotes ADR1-L1 oligomerization, crucial for immune activation and cell death.

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

Experimental evidence pointing to rain as a reservoir of tomato phyllosphere microbiota

The paper tests if rain is a reservoir of tomato phyllosphere microbiota by comparing microbial communities on rain-exposed and protected tomato leaves.

N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B

This study identifies NRG1C, an N-terminally truncated helper NLR in Arabidopsis, which antagonizes immunity mediated by its full-length relatives NRG1A and NRG1B.

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

Deciphering Functional Redundancy in the Human Microbiome

The paper investigates functional redundancy in the human microbiome by analyzing genomic content networks and developing a genome evolution model to explain their topological features.

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction

The paper demonstrates that NC410, a LAIR-2 Fc protein, blocks LAIR-1-collagen interaction, enhancing T cell activity and reducing tumor growth in humanized models.