M. M. Davis

The role of antigen recognition in the γδ T cell response at the controlled stage of M. tuberculosis infection.

This study identifies a distinct CD8+γδ T cell population in controlled Mtb infection that exhibits NK-like cytotoxicity and stage-specific antigen recognition.

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

Single-cell sequencing unveils distinct immune microenvironment with CCR6-CCL20 crosstalk in human chronic pancreatitis

This study uses single-cell sequencing to identify distinct immune features and CCR6-CCL20 crosstalk in hereditary versus idiopathic chronic pancreatitis.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.

EpiSort: Enumeration of cell types using targeted bisulfite sequencing

EpiSort uses targeted bisulfite sequencing to accurately enumerate 23 cell types in tumors, offering a new approach for cancer microenvironment analysis.

Clonal replacement of tumor-specific T cells following PD-1 blockade

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.

SIMON, an automated machine learning system reveals immune signatures of influenza vaccine responses

SIMON, an automated machine learning system, identifies immune signatures of influenza vaccine responses by analyzing clinical datasets with missing values.

Immuno-proteomic interrogation of dengue infection reveals novel HLA haplotype-specific MHC-I antigens

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.

Dynamics Of The Human Antibody Repertoire Following B-cell Depletion In Systemic Sclerosis

This study examines changes in the B-cell antibody repertoire in SSc-PAH patients before and after B-cell depletion, revealing anomalies in B-cell development and homeostasis that reverse temporarily.